This case control study was carried out among Kaha Food Industrial Workers in Qualoubia and Sharkia Governorates to investigate some biochemical features of Active Billharziasis. Sixty cases and twenty one controls were selected to be the material of this work. Biochemical studies were done at Environmental laboratory of Occupational Health National Research Center, using Atomic Absorption Spectrophotometry. From the results of this study, it is concluded that : Serum copper and ceruloplasmin levels were significantly increased in active billharziasis, while there is a significantly hypozincemia and hypomagnesimia in the studied cases. Also there is a significant decrease in haemoglobin levels when compared with controls. Liver function tests showed more derangement in active bilharziasis. These results were discussed and interpreted and suitable recommendations for further researches were recommended.