Abstract Background: Tuberculosis (TB) is a major cause of illness and death worldwide, especially
in Asia and Africa. In the early 1990s tuberculosis control in Egypt faced many problems. Major progress
in global tuberculosis control followed the widespread implementation of the DOTS strategy.
Aim: The objective of this work was to study the tuberculosis situation in Port Said governorate
from (1995–2011) before and after Direct Observed Therapy Short Course Strategy (DOTS).
Methods: This was a retrospective clinical cohort study carried out at the Port Said governorate.
The registered data about all TB cases over a period of 16 years (1995–2011) before and after the
application of DOTS were collected from the chest hospital and TB registration units.
Results: Percentages of cure and complete treatment significantly increased after DOTS (48.7%
and 29.3% respectively) than before (19.5% and 13.7% respectively) (P