Introduction: Varicocele is an abnormal dilatation and torticulation in pampiniform plexus of veins within the spermatic cord. It involves about 15% of young males. It is considered the most common urologic problem in whole adolescence. Physical examination considered the important examination in screening for varicocele in adolescence. Patients and Methods: Three hundred boys with agree range from 12 – 15 years old were chosen for this study. Physical and general examination was done in the outpatient clinics. Color duplex ultrasonography was done for all boys with standard protocol in erect and supine positions with and without Valsalva maneuver. Varicocelectomy was done in 5 boys after acceptance of their parents. Results: On physical examination 13.6% had unilateral varicocele while on color duplex examination 15.3% of the examined boys had unilateral varicocele that classified into grade I (8%), grade II (5.6%), grade III (1.3%) and grade IV (0.3%). 8% represent grade I. Conclusion: Our conclusion: by one non invasive screening examination with color duplex ultrasonography we can increase the accuracy of detecting varicocele in adolescence with subsequent prevention of their damage effect on testis.