Staff Members - Benha University
Intervention Program for Improving Insulin Sensitivity and Ameliorating Adipokines altered Serum Levels in Obese and Type-2 Diabetic Children
• 2016
Publication Information
Authors
Adel F. Al-Kholy MD, Omminea A. Abdullah MD, Manal M. Hassaan,
Ashraf M.Shaheen MD, Yehia H. Abdel Maqsoud MD, Shereen M. Wahab MD, Eman M. Shaheen MD Maha MD, Emtethal A. Said MD,
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publication.type
International
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Abstract
Objectives: To evaluate therapeutic yield of lifestyle intervention program on body
mass index (BMI), insulin resistance (IR) and estimated laboratory markers in obese
and diabetic children.
Patients & Methods: Thirty-five obese non-diabetic, 35 type-II diabetic and 20 control
children and adolescents were studied. All study children underwent 12-weeks
intervention consisted of dieting regimen, aerobic exercise with curcumin as herbal
therapy. All patients gave blood samples for ELISA estimation of serum insulin,
progranulin (PGRN), tumor necrosis factor-α (TNF-α), adiponectin and YKL-40
levels. Insulin resistance was measured by homeostasis model assessment (HOMAIR).
Body weight (BW), BMI and HOMA-IR score and laboratory parameters were
determined at start and end of the intervention.
Results: At end of intervention, BW and BMI, and HOMA-IR variables and score
were significantly decreased compared to baseline measures. Patients had
significantly higher baseline serum levels of PGRN, YKL-40 and TNF-α, but
significantly lower serum adiponectin levels than controls and in diabetics compared to obese children. At end of intervention, serum PGRN and YKL-40 levels were
significantly decreased compared baseline levels, despite being still significantly
higher than control levels. Serum PGRN and YKL-40 levels were still significantly
higher in diabetics than obese patients. Serum levels of TNF-α were still significantly
higher in patients than in controls and in diabetics than in obese patients. In
comparison to baseline levels, serum levels of TNF-α were significantly lower in
obese but non-significantly lower in diabetics. Serum adiponectin levels were
significantly lower in diabetics and non-significantly lower in obese compared to
control levels, but were significantly higher in obese and non-significantly higher in
diabetics compared to their baseline levels with significantly higher levels in obese
compared to diabetics.
Conclusion: The proposed intervention program allowed reduction of BW and IR and
could ameliorate disturbance of adipokines serum levels in obese and diabetic
children.
mass index (BMI), insulin resistance (IR) and estimated laboratory markers in obese
and diabetic children.
Patients & Methods: Thirty-five obese non-diabetic, 35 type-II diabetic and 20 control
children and adolescents were studied. All study children underwent 12-weeks
intervention consisted of dieting regimen, aerobic exercise with curcumin as herbal
therapy. All patients gave blood samples for ELISA estimation of serum insulin,
progranulin (PGRN), tumor necrosis factor-α (TNF-α), adiponectin and YKL-40
levels. Insulin resistance was measured by homeostasis model assessment (HOMAIR).
Body weight (BW), BMI and HOMA-IR score and laboratory parameters were
determined at start and end of the intervention.
Results: At end of intervention, BW and BMI, and HOMA-IR variables and score
were significantly decreased compared to baseline measures. Patients had
significantly higher baseline serum levels of PGRN, YKL-40 and TNF-α, but
significantly lower serum adiponectin levels than controls and in diabetics compared to obese children. At end of intervention, serum PGRN and YKL-40 levels were
significantly decreased compared baseline levels, despite being still significantly
higher than control levels. Serum PGRN and YKL-40 levels were still significantly
higher in diabetics than obese patients. Serum levels of TNF-α were still significantly
higher in patients than in controls and in diabetics than in obese patients. In
comparison to baseline levels, serum levels of TNF-α were significantly lower in
obese but non-significantly lower in diabetics. Serum adiponectin levels were
significantly lower in diabetics and non-significantly lower in obese compared to
control levels, but were significantly higher in obese and non-significantly higher in
diabetics compared to their baseline levels with significantly higher levels in obese
compared to diabetics.
Conclusion: The proposed intervention program allowed reduction of BW and IR and
could ameliorate disturbance of adipokines serum levels in obese and diabetic
children.