Background: Tympanic membrane (TM) perforations can arise from a variety of causes; Major causes include trauma and middle ear disease. Surgical treatment requires higher costs, more effort and surgical risks. Therefore, many investigators have studied topical use of substances to facilitate TM repair (1). Estrogen can influence the various phases of wound healing in cutaneous repair; Topical estrogen application may influence the repair of TM perforations.
Aim of the work: The aim of the work is to evaluate new procedure for repairing of TM perforation and improving hearing threshold after 30 days using estrogen paper patch.
Patients and methods: After getting informed consent, patients were randomly allocated to two groups. One group was treated with estrogen paper patch (paper patch impinged with1% estrogen ointment to act as the study group), The second group was treated with paper patch impinged with local antibiotic ointment to act as the control group (we used 1% tetracycline ointment in our study).
Conclusion: maybe there is significant and promising result for estrogen paper patching as a method of repairing tympanic membrane perforation.