Staff Members - Benha University
Expression of PD-1/PD-L1 and P53 in hepatocellular carcinomarelationship with clinicopathological parameters
Egyptian Journal of Pathology • 2018
Publication Information
Authors
Bassyoni, Omneya Y.; Rashad, Heba M.
Keywords
Not Available
Journal
Egyptian Journal of Pathology
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Previously described immune checkpoint regulators, programmed cell death (PD-1) and its main ligand (PD-L1) are known to regulate T-cell function and control proliferation of tumor cells. A connection between P53 and those checkpoint has been reported in cancer cells. This work aimed at studying the expression for PD-1/PD-L1 and P53 protein in hepatocellular carcinoma (HCC) and correlate them with clinicopathological parameters.
Materials and methods
Immunohistochemical expression of PD-1/PD-L1 and P53 was evaluated in 33 cases of HCC and eight cases of non-neoplastic liver samples (hepatitis) were used as control.
Results
PD-1/PD-L1 and P53 showed higher expression in HCC cases compared to non-neoplastic liver tissue (P
Materials and methods
Immunohistochemical expression of PD-1/PD-L1 and P53 was evaluated in 33 cases of HCC and eight cases of non-neoplastic liver samples (hepatitis) were used as control.
Results
PD-1/PD-L1 and P53 showed higher expression in HCC cases compared to non-neoplastic liver tissue (P