Staff Members - Benha University
Significance of insulin-like growth factor II mRNA-binding 1 protein 3 expression in selected thyroid lesions
Benha Medical Journal 2018 , under publication • 2018
Publication Information
Authors
Taghreed Abd El Samee Abd El Aziz, Ranih Z. Amer, Omnia Y. Bassyoni Hanan A. Sayed-Ahmed
Keywords
insulin-like growth factor II mRNA-binding protein 3, insulin-like growth factor, thyroid lesions
Journal
Benha Medical Journal 2018 , under publication
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Background
Differentiation of benign from malignant-follicular thyroid lesions remains difficult and the ability of the molecular markers to differentiate between them is still not clear. The aim of this study is to evaluate the usefulness of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression to distinguish benign from malignant thyroid lesions.
Patients and methods
This is a retrospective study on 57 selected thyroid lesions designated as: seven cases of Hashimoto thyroiditis, 10 cases of hyperplastic nodules, 15 cases of follicular thyroid adenoma, 13 cases of conventional papillary thyroid carcinoma, six cases of follicular variant of papillary thyroid carcinoma, and six cases of follicular thyroid carcinoma. Immunohistochemistry was applied on formalin-fixed, paraffin-embedded tissue blocks using IMP3. The clinicopathological data were reviewed from patients’ pathological reports and were correlated with IMP3 expression.
Results
IMP3 positivity was seen in one of the seven (14.3%) cases of Hashimoto thyroiditis, two of the 10 (20%) cases of hyperplastic nodule, four of the 15 (26.7%) cases of follicular thyroid adenoma, 12 of the 13 cases of papillary thyroid carcinoma, and in all (100%) follicular variant of papillary thyroid
carcinoma and follicular thyroid carcinoma cases. IMP3 staining was significantly increased from normal thyroid tissue to malignant tumors (P
Differentiation of benign from malignant-follicular thyroid lesions remains difficult and the ability of the molecular markers to differentiate between them is still not clear. The aim of this study is to evaluate the usefulness of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression to distinguish benign from malignant thyroid lesions.
Patients and methods
This is a retrospective study on 57 selected thyroid lesions designated as: seven cases of Hashimoto thyroiditis, 10 cases of hyperplastic nodules, 15 cases of follicular thyroid adenoma, 13 cases of conventional papillary thyroid carcinoma, six cases of follicular variant of papillary thyroid carcinoma, and six cases of follicular thyroid carcinoma. Immunohistochemistry was applied on formalin-fixed, paraffin-embedded tissue blocks using IMP3. The clinicopathological data were reviewed from patients’ pathological reports and were correlated with IMP3 expression.
Results
IMP3 positivity was seen in one of the seven (14.3%) cases of Hashimoto thyroiditis, two of the 10 (20%) cases of hyperplastic nodule, four of the 15 (26.7%) cases of follicular thyroid adenoma, 12 of the 13 cases of papillary thyroid carcinoma, and in all (100%) follicular variant of papillary thyroid
carcinoma and follicular thyroid carcinoma cases. IMP3 staining was significantly increased from normal thyroid tissue to malignant tumors (P