Myocardial infarction (MI) is an irreversible injury or subsequent necrosis of myocardial cells due to interruption of blood supply to a part of the heart.The present study was designed to evaluate the effect of ezetimibe, atorvastatin and their combination on model of induced acute myocardial infraction with hypercholesterolemic rats. Animals were classified into group 1: control group which was subclassified to normal control group (received standered chow) and vehicle group (received 0.5% carboxymethyl cellulose), group 2: hypercholestermic group with no medication (induced by 2% cholesterol for 6 weeks) group 3: hypercholestermic infracted group with no medication (diseased group) (induced by s.c injection of isoprenaline at a dose of 150mg/kg diluted in 2ml of saline), group 4: Atorvastatin (8mg/kg) pretreated-hypercholesterolemic infarcted group, group 5: Ezetimibe (1mg/kg) pretreated-hypercholesterolemic infarcted group, Group 6: Ezetimibe (1mg/kg) and atorvastatin (4mg/kg) pr-treated hypercholesterolemic infarcted group, Group 7: Ezetimibe (1mg/kg) and Atorvastatin (8mg/kg) pretreated-hypercholesterolemic infarcted group.. All tested drugs showed improvement of lipid profile, compared to control normal group and diseased group. All treated groups showed significant results compared to ezetimibe 1mg/kg alone. Regarding MI, Atorvastatin 8mg/kg only showed improvement of parameters of MI, but ezetimibe had no role. Conclusively: All drugs used in this study improve lipid profile, while only atorvastatin in high dose improve parameters of MI.