Cancer is a genome disease, initiated by mutations in genes that usually
control cell growth and division. Matrix metalloproteinases (MMPs)
have important roles in both of tumor invasion and spread. The present
study was conducted to evaluate the effect of ionizing radiation (in the
level of treatment doses of γ-rays). The action of collagenase gene was
examined in vivo by using a model of solid tumor carcinoma (EAC).
Eighty male mice were used for this experiment; it is divided into 8
groups, 10 mice / each; which were Normal, beside three groups of
normal mice and three groups of tumor transplanted mice each of them
exposed to the following accumulated doses (6, 9 and12 Gy). Whole
body mice were exposed to gamma radiation from Cobalt-60 (
60
Co)
twice a week for three weeks with different doses after 12 days of
injected ehirlich tumor in the right thigh region. The different doses of
ionizing radiation exposure resulting in different changes (Mutations)
on the sequence of collagenase gene in normal and malignant
implanted groups and the level of these mutations were height in the
malignant groups.
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