Staff Members - Benha University
Original Article Steroid Responsiveness and Urinary Monocyte Chemotactic Protein-1 in Children with Nephrotic Syndrome.
• 2022
Publication Information
Authors
Omima Mohamed Abdel haie1, Abdel Hamid Salah El hamshary1, Asmaa Adel El Falah2,
Ashraf Roshdy Mohammed Swidan3, Wesam EL Menshawy Afifi
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Introduction: Idiopathic nephrotic syndrome is a clinical syndrome marked by a significant loss of urine
protein, resulting in hypoproteinemia and edema.The recruitment of monocytes/macrophages into the
renal tubulointerstitium is aided by the moncyte chemotactic protein-1.
Aim of the study: The aim of our study was planned to measure the level of monocyte chemotactic
protein 1 in the urine of children with idiopathic nephrotic syndrome during disease activity and
remission as well as in steroid sensitive and steroid resistant cases to identify a possible predictive
biomarker of disease activity and/or steroid responsiveness.
Methods: This prospective study comprised 50 patients with nephrotic syndrome who were followed up
on at Pediatric Nephrology Clinic and Department, Benha University, and were divided into two groups:
group A (cases in remission) and group B (cases in activity). Also, 20 age and sex matched healthy
children have been included as a control group.
Results: We found a significant increase in urinary moncyte chemotactic protein-1(uMCP-1) in
idiopathic nephrotic syndrome patients as compared to control group (p < 0.001). Also, the greatest levels
of uMCP-1 were found in group B, followed by group A, and then the control group (p
protein, resulting in hypoproteinemia and edema.The recruitment of monocytes/macrophages into the
renal tubulointerstitium is aided by the moncyte chemotactic protein-1.
Aim of the study: The aim of our study was planned to measure the level of monocyte chemotactic
protein 1 in the urine of children with idiopathic nephrotic syndrome during disease activity and
remission as well as in steroid sensitive and steroid resistant cases to identify a possible predictive
biomarker of disease activity and/or steroid responsiveness.
Methods: This prospective study comprised 50 patients with nephrotic syndrome who were followed up
on at Pediatric Nephrology Clinic and Department, Benha University, and were divided into two groups:
group A (cases in remission) and group B (cases in activity). Also, 20 age and sex matched healthy
children have been included as a control group.
Results: We found a significant increase in urinary moncyte chemotactic protein-1(uMCP-1) in
idiopathic nephrotic syndrome patients as compared to control group (p < 0.001). Also, the greatest levels
of uMCP-1 were found in group B, followed by group A, and then the control group (p