Background: Neonatal seizures are the most prevalent neurological disorders. In Egypt, the characteristics and
neurodevelopmental outcomes of neonatal seizures have not been sufficiently explored.
Methods: The present study was conducted on 120 full-term and preterm newborns from October 2016 and
October 2020. The adverse outcomes of cerebral palsy, mortality, developmental delay, and/or epilepsy have been
considered. The associations between adverse outcomes and 13 variables were analyzed.
Results: Hypoxic-ischemic encephalopathy (HIE) (34.2%) was the most common etiology for neonatal seizures,
followed by intracranial hemorrhage (25.8%). The predominant seizure type was subtle (57.5%), preceded by
clonic seizure (16.7%). Moreover, 72 neonates had a normal outcome, 14 (60%) cases had minor functional
disabilities, and 27 (22.5%) newborns survived with one or more neurodevelopmental abnormalities (6 cases had
cerebral palsy, and 21 newborns had global developmental delay), with a 17.5 % mortality rate. Based on the
univariate analysis, 10 variables were associated with an unfavorable outcome; nonetheless, only three variables,
namely metabolic acidosis, abnormal cranial ultrasonography findings, and the presence of congenital heart disease,
were independent predictors as illustrated by multivariate logistics.
Conclusion: As evidenced by the obtained results, HIE and intracranial hemorrhage were the most common causes
of neonatal seizures. Perinatal insult, prematurity, seizure onset