| publication name | Significant hepa c expressi on of IL-2 and I L-8 i n bil iary atr esi a compa r ed wit h other neonatal cholesta c di sor der s |
|---|---|
| Authors | Reda S Arafa, MD; Omima M Abdel Haie, MD; Dina S El-Azab, MD; Amira M Abdel-Rahman, MSc; Mostafa Mohamed Sira, M.D |
| year | 2016 |
| keywords | biliary atresia; interleukin 2, interleukin 8, e opat hogenesi s; i mmu nostai ni ng, neonatal cholestasis |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Objectives: Although the exact etiology of biliary atresia (BA) is still elusive, inflammation plays a key role. Release of proinflammatory cytokines from activated immune cells perpetuates the injury and causes biliary destruction. We aimed to study interleukin (IL)-2 and IL-8 expression in liver tissue of BA patients compared with other neonatal cholestatic disorders. Methods: The study included 59 infants with neonatal cholestasis in two groups; BA group (n=31) and non-BA group (n=28) with cholestatic disorders other than BA as controls. Demographic, clinical, laboratory, and histopathological parameters were collected. IL-2 and IL-8 immunostaining was performed. Immunostaining in portal cellular infiltrate was scored as positive or negative and expressed as the mean cell count in three portal tracts. Results: The mean value of IL-2 and IL-8 positive inflammatory cells was significantly higher in BA than in non-BA group (P-values of 0.004 and 0.002 respectively). IL-2 correlated significantly with IL-8 immunostaining in both BA and non-BA group (P