Genetic polymorphisms of the E-selectin are associated with coronary artery disease. Objectives: We aimed to investigate the association between the A561C and G98T polymorphisms in E-selectin gene and coronary artery disease in Egyptian population. Subjects & methods: The study enrolled 251 individuals, classified into 2 groups: 152 coronary artery disease patients and 99 normal healthy individuals. A561C and G98T polymorphisms of E-selectin were analyzed by PCR-RFLP (Polymerase chain reaction - Restriction fragment length polymorphism) technique. Results: The frequency of C allele of the E selectin A561C polymorphism was higher in coronary artery disease patients than control group but with no statistical significant difference between the two studied groups (p=0.53). The frequency of T allele of G98T polymorphism of E-selectin was higher in coronary artery disease patients when compared to control group but with no statistical significant difference (P=0.36). Conclusion: A561C and G98T polymorphisms of E-selectin gene are not associated with the predisposition to coronary artery disease and appear to be protective in Egyptian population.