Staff Members - Benha University
Association of Monocyte Chemoattractant Protein-1 (MCP-1) 2518A/G Gene Polymorphism with Proliferative Diabetic Retinopathy in Patients with Type 2 Diabetes
• 2015
Publication Information
Authors
Mona El-Tokhy1, Eman Ramadan Abdel Gwad1, Walid Abdel Ghaffar2, Ola Serag1
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publication.type
International
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Abstract
MCP-1 is a member of the CC chemokine family and acts chemotactically on monocytes
and induces monocyte and macrophage infiltration into tissues. Hyperglycemia induces MCP-1 production in
vascular endothelial cells and retinal pigmented epithelial cells, and has been implicated as a causal factor in the
facilitation of vascular complications in diabetes. In the present study, we evaluated the association of a single
nucleotide polymorphism (SNP) in the MCP-1 gene with proliferative diabetic retinopathy (PDR) in egyptian
population with type 2 diabetes. Patients and Methods: We conducted a case-control study, which included 50
subjects with type 2 diabetes. SNP genotyping of c.2518A/G in the MCP-1 gene was performed using polymerase
chain reaction followed by digestion with PvuII restriction enzyme. Results: The prevalence of c.2518A/G
polymorphism in diabetic patients was 52% (A/A), 34% (A/G) and 14% (G/G). In patients with diabetic retinopathy,
the prevalence of PDR was significantly higher (p
and induces monocyte and macrophage infiltration into tissues. Hyperglycemia induces MCP-1 production in
vascular endothelial cells and retinal pigmented epithelial cells, and has been implicated as a causal factor in the
facilitation of vascular complications in diabetes. In the present study, we evaluated the association of a single
nucleotide polymorphism (SNP) in the MCP-1 gene with proliferative diabetic retinopathy (PDR) in egyptian
population with type 2 diabetes. Patients and Methods: We conducted a case-control study, which included 50
subjects with type 2 diabetes. SNP genotyping of c.2518A/G in the MCP-1 gene was performed using polymerase
chain reaction followed by digestion with PvuII restriction enzyme. Results: The prevalence of c.2518A/G
polymorphism in diabetic patients was 52% (A/A), 34% (A/G) and 14% (G/G). In patients with diabetic retinopathy,
the prevalence of PDR was significantly higher (p