Staff Members - Benha University
Synthesis of Novel Series of Phthalazine Derivatives as Potential Antitumor Agents
Chemical and Process Engineering Research • 2013
Publication Information
Authors
Ashraf Farouk Wasfy *, Aly Abdelmaboud Aly, Mohamed Sayed Behalo, Nora Sobhi Mohamed
Keywords
: Phthalazin-1-(2H)-One; chlorophthalazine; isoindol-1,3-dione; antitumor activity.
Journal
Chemical and Process Engineering Research
Publisher
Not Available
Volume
10
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
A novel series of phthalazine derivatives bearing isoindol-1,3-dione moiety were synthesized by treating 2-[4-(4chlorophthalazine-1-yl)phenyl]-1H-isoindole-1,3-(2H)-dione 3 with various chemical reagents.The newly synthesi- zed compounds were characterized on the basis of their spectral (1H NMR, 13C NMR, Ms, IR) analyses. In vitro, most of the synthesized derivatives were screened for their antitumor activity against HepG2 cells using MTT assay. Compounds 11, 18 and 19c showed the most potent cytotoxic effect concluded from their IC50 values 217.4, 240.3 and 234.5 µg/ml respectively.