Hussien NI, Shoman AA. Effect of obesity and passive smoking on
biochemical and histopathological changes in rat Liver and the
protective effect of exercise. JEPonline 2013;16(4):101-111. Obesity
has various effects on hepatic function. There is little information
available for effects of exercise on biochemical and histopathological
changes in the liver of obese rats. In addition the prevalence of
cigarette smoking (CS) is increased among obese subjects, who are
susceptible to develop fatty liver disease. The purpose of this study
was to determine the effect of exercise and passive smoking on body
mass index, serum lipid profile (LDL and HDL cholesterol), blood
glucose, aspartate aminotransferase (AST), alanine aminotransferase
(ALT), albumin level and liver histology in rats fed high-sucrose diet.
The rats were classified into 5 main groups: Group I, Control Group;
Group II, High Sucrose Untrained Group Not Exposed to Passive
Smoking; Group III, High Sucrose Trained Group; Group IV, High
Sucrose Group Exposed to Passive Smoking; Group V, High Sucrose
Trained Group Exposed to Passive Smoking. The findings from this
study indicate that obesity induced by high sucrose diet caused
significant increase in body mass index, serum triglycerides, total
cholesterol, LDL−C, blood glucose, AST, and ALT as well as a
significant decrease in albumin and serum HDL−C with significant
changes in liver histology. All these effects were counteracted by
exercise and were ameliorated by smoking. Preventing and treating
obesity will be a key measure in preventing and controlling this
epidemic of fatty liver disease.