Objectives: The current study tried to determine the effects of exposure to fumonisins on kidney and liver func- tions tests and sphingolipid metabo- lites. Patients & Methods: 80 apparently healthy participants of Area 1(A1) that was considered as area heavily contaminated by fumonisins and Area 2 (A2) that was considered as low con- tamination area. Ten urban volunteers were enrolled as a control group. All participants underwent full history taking, complete clinical examination with special regard to liver and kidney and gave blood samples for estimation of serum levels of aspartate transami- nase (AST), alanine transaminase (ALT), urea, creatinine, and plasma lipid profile, and ELISA estimation of plasma sphingosine-1-phosphate (S1P) levels