Staff Members - Benha University
Serum and synovial survivin in rheumatoid arthritis: Relation to disease activity and severity
Egyptian Rheumatology & Rehabilitation • 2019
Publication Information
Authors
Eman Barakaa, Mounir Serag El Dina, Ahmed El Shambkya, Nehad A. Fouadb,
Mona Abdullah Abdelkader
Keywords
Not Available
Journal
Egyptian Rheumatology & Rehabilitation
Publisher
Not Available
Volume
46:221–228
Issue
Not Available
Pages
46:221–228
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Rheumatoid arthritis (RA) is a progressive debilitating autoimmune disease,
affecting 1% of the world population, leading to cartilage and bone destruction
caused by insufficient apoptosis in the inflamed RA synovium. Survivin is a protooncogene biomarker known for its anti-apoptotic and cell cycle-regulating
properties. Overexpression of survivin in non-cancerous processes has been
linked to inflammation, presumably contributing to the decreased apoptosis in
the T cells of the cerebrospinal fluid in multiple sclerosis, in skin lesions of
patients with psoriasis and in synovial tissue of patients with RA.
affecting 1% of the world population, leading to cartilage and bone destruction
caused by insufficient apoptosis in the inflamed RA synovium. Survivin is a protooncogene biomarker known for its anti-apoptotic and cell cycle-regulating
properties. Overexpression of survivin in non-cancerous processes has been
linked to inflammation, presumably contributing to the decreased apoptosis in
the T cells of the cerebrospinal fluid in multiple sclerosis, in skin lesions of
patients with psoriasis and in synovial tissue of patients with RA.