Staff Members - Benha University
Novel marker in proliferative and involuting phases of infantile hemangioma
Journal of the Egyptian Women • 2020
Publication Information
Authors
Neveen E. Soroura, Hanan H. Sabrya, Amal O. Hadhoudb, Asmaa A. Elfalahc
Keywords
galectin-3, infantile hemangioma, pro-angiogenic, proliferative
Journal
Journal of the Egyptian Women
Publisher
Wolters Kluwer - Medknow
Volume
17
Issue
Not Available
Pages
152-157
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background
No single theory can explain the characteristics of infantile hemangioma (IH), but
the emergence of new biomarkers will help to discover a general mechanism in its
pathogenesis.
Objective
To evaluate serum level of galectin-3 (gal-3) in patients with IH and its possible role
in the pathogenesis during proliferative and involuting phases.
Patients and methods
This case–control study included 60 patients with IH as group 1 (G1). They were
subdivided into 30 patients with age ranged from 3 to 12 months (proliferative
phase, G1A) and 30 patients with age ranged from more than 12 to 24 months
(involuting phase, G1B). In addition, 20 age-matched and sex-matched healthy
participants who served as a control group (G2) were included. The diagnosis was
based on clinical bases and ultrasonic examination. Assessment of serum level of
gal-3 was done by enzyme-linked immunosorbent assay kits in all studied groups
and was correlated with clinical findings of IH.
Results
Serum gal-3 levels were significantly higher in the patient group (G1) than controls
(G2) (P=0.001). Serum gal-3 levels were significantly higher in G1B compared with
G1A and controls (G2B) (P
No single theory can explain the characteristics of infantile hemangioma (IH), but
the emergence of new biomarkers will help to discover a general mechanism in its
pathogenesis.
Objective
To evaluate serum level of galectin-3 (gal-3) in patients with IH and its possible role
in the pathogenesis during proliferative and involuting phases.
Patients and methods
This case–control study included 60 patients with IH as group 1 (G1). They were
subdivided into 30 patients with age ranged from 3 to 12 months (proliferative
phase, G1A) and 30 patients with age ranged from more than 12 to 24 months
(involuting phase, G1B). In addition, 20 age-matched and sex-matched healthy
participants who served as a control group (G2) were included. The diagnosis was
based on clinical bases and ultrasonic examination. Assessment of serum level of
gal-3 was done by enzyme-linked immunosorbent assay kits in all studied groups
and was correlated with clinical findings of IH.
Results
Serum gal-3 levels were significantly higher in the patient group (G1) than controls
(G2) (P=0.001). Serum gal-3 levels were significantly higher in G1B compared with
G1A and controls (G2B) (P