Bipolar disorder is characterized by mood swings with both manic and depressive symptoms. Social cognitive abnormalities have recently been recognized as a core feature of mood disorders which persist during remission. The neuropeptide oxytocin may be a trait marker of bipolar disorder and it’s dysregulation might be involved in the pathophysiology of bipolar disorder. Aim of the study: To compare oxytocin levels between cases of bipolar disorders and control group and to search for a correlation between oxytocin levels and various clinical parameters. Methods: Forty five (45) bipolar patients and thirty (30) healthy controls with matching age and sex were examined. SCIDI was for confirmation of diagnosis of bipolar disorder. Further assessment using Beck depression inventory, Young mania scale were also performed. Salivary Oxytocin hormone level was also measured. Results: Oxytocin showed higher significant levels in bipolar patients whether in depression, mania or in remission when compared to controls (p