Background: Organizational excellence is a challenge that can be met through human resources management, which aids educational organizations in enhancing and increasing their capacity for productivity and competitiveness in their field. The study aimed to assess organizational excellence and its relation to human resources management as perceived by academic teaching staff. Design: A descriptive correlational design was utilized. Setting: The study was conducted in all academic departments at the Faculty of Nursing, Benha University. Subjects: Included all available academic teaching staff 103 in all academic departments at the Faculty of Nursing, Benha University. Two tools were used for data collection: Organizational Excellence Questionnaire, Human Resources Management Questionnaire. Results: Showed that the majority (91.3%) of the academic teaching staff perceived high level of organizational excellence and the most (82.5%) of them perceived high level of human resources management. Conclusion: The study concluded that, there was highly statistically significant positive correlation between total organizational excellence and total human resources management as perceived by the academic teaching staff. The study recommended that the Faculty administration should intensify the training of the academic staff on the standards of excellence management through seminars, workshops and forums. In addition to, providing continuous feedback individually to the academic teaching staff for identifying their strengths and weakness in the performance.