| publication name | A comparative study between some pharmacological effects of rilmenidine versus captopril on experimentally-induced diabetic nephropathy in rats. |
|---|---|
| Authors | Nasr N. Makar, Ahmed S. Mohamed, Mahmoud M. Al_Fouly, Samia M. Al-Sheety, Nashwa H. Abu_Ria. |
| year | 2010 |
| keywords | |
| journal | THE ANNUAAL MEDICAL CONGRESS BENHA FACALTY OF MEDICINE |
| volume | Not Available |
| issue | 5 |
| pages | 21 |
| publisher | THE ANNUAAL MEDICAL CONGRESS BENHA FACALTY OF MEDICINE |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
AIM: to assess the effects of both rilmenidine and captopril on fasting blood glucose (FBG) level, urine albumin. and kidney histopattrotogy in streptozotocin (STZ)-induced diabetic nephropathy rats. METHOD: 24 spraruge Dawley male rats weighing berween 150-250g were administered single dose STZ (l00mg/kg) intraperionially and examined after 4 weeks for FBG, urine albumin and.kidney histopathology. the rats were divided into 4 groups: normal contror, diabetic nephropathy, rilmenldine-treated and captopril-treated groups. Rats received rilmenidine (lmg/kg/day) intraperitonially for 4 weeks and captopril (100mg/kg/day) orally for 4 weeks. RESULTS: rimenlidine significantly decreased FBG and significantly reduced urine albuimin. captopril significantly (p