Staff Members - Benha University
NITROGLYCERIN AS AN ERECTILE AGENT, EVALUATION oF ITS POSSIPLE EFFECTS ON SPERM ATOZOA AND TERATOGINICITY
Accepted in 40th Annual Conference of The Egyptian Society Of Pharmacology and Experimental Therapeutics • 1996
Publication Information
Authors
Mohie-Aldien A. Sherief and Nsr Nzmy
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Accepted in 40th Annual Conference of The Egyptian Society Of Pharmacology and Experimental Therapeutics
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publication.type
Local
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Abstract
Nitric oxide (No) donners are used topicaly for treatment of impotence. This use
leads to contamination of ejaculated sperms with this ug.nt, ond also there is a
chance of diffrrsion of these agents to the embryo 1if ii is p*;rr0. Tliis rvork ras designed to evalulate the effect of nitroglycerin adhesi'e patches
(nitroderm TTS-5) r,vhich is a donner of No used topiiaty on hu.ran permatozao
and rat's enbrvo.
Semen samples lvere obtained from fertile donners, patients with varicocele and paitents l'ith chronic prostatis each- sarnple rvas examined for viability and mortalig' in presence or in absence of nitrogtycerin. Samples from feriile males
r.r,ere examined for vialbility and motility in presence of Nitroglycerin or Ham fl0.
Nitroglvcerin imporoved viability and motility of sperms ouialneo from fertile
men signifi cantly (p0.5) improvment of sperm viability and the improvrnent in sperm motility rgached significant level at 3rd, 5th and 6th
hour in samples obtained from patignt rvith v-aricocele. Samples obtained from
patients rvith chronic prostatitis shorvs significant (p
leads to contamination of ejaculated sperms with this ug.nt, ond also there is a
chance of diffrrsion of these agents to the embryo 1if ii is p*;rr0. Tliis rvork ras designed to evalulate the effect of nitroglycerin adhesi'e patches
(nitroderm TTS-5) r,vhich is a donner of No used topiiaty on hu.ran permatozao
and rat's enbrvo.
Semen samples lvere obtained from fertile donners, patients with varicocele and paitents l'ith chronic prostatis each- sarnple rvas examined for viability and mortalig' in presence or in absence of nitrogtycerin. Samples from feriile males
r.r,ere examined for vialbility and motility in presence of Nitroglycerin or Ham fl0.
Nitroglvcerin imporoved viability and motility of sperms ouialneo from fertile
men signifi cantly (p0.5) improvment of sperm viability and the improvrnent in sperm motility rgached significant level at 3rd, 5th and 6th
hour in samples obtained from patignt rvith v-aricocele. Samples obtained from
patients rvith chronic prostatitis shorvs significant (p