-{pproximatcly 15 7o of couples attempting their first pregn'lncy rneet with failure' It is not uncommon to meet a male factor or inrertitity due to idiofiathic spermatogenic a rrest. This stucly aimcd to assess the effect of both lormonal and non-hoimonal therapy df inferiitity' Pentoxifylline (PTXXISS mg/kg/day)' Lcarnitine( l00mg/kg/day) -uno t""o*Uinant follicie stimulating trormone (r-FSH) (30 lUikg every other day) were rused in spermatogenic arrested rat modet (previously tt-*tga.rvith S'C' administration'ot 25 mg/kg /day colchicine). The seminal fluid parameters, testicular liistologicat changes and serun levelsofFSH'LH'and ;;il;i;; rr.ere studied. colchicine administration produced a markecl and statistically signi{icant decrease in seminal parsmeters and spermatogenells. prX treated rat model showed a statistically significant increase in ,plir" "i' count (pg.is ). seuri FsH, LH nrrd prolactin levcls shorvcd no statistir:ally significant deviation front normal corrtrol levels. pTX giveu together t"ittr u carnitine, rcvcalecl a statistically significant intprovement in all sperm paramerers and in iesticuh; histology. It showed-a-statistically significant itrcrease in sperm celt count ,*obil sierm viability (p