Sexual problems are highly prevalent in both men and women and are affected by,among other factors, mood state, interpersonal functioning, and psychotropic medications. Inspite of the evidence suggesting that many victims of depression may compiain of sexual dysfunction which by itself may add much to depression, also many antidepressants may augment sexual dysfunction. this study reviews current evidence regarding sexual side effects of antidepressant as delayed ejaculation absent or delayed orgasm, decreased desire and arousal difficulties. In order to clarify these issuses 20 mg of imipramine hydrochloride for 15 days were administered to Sprague-Dawley rats to have a depressed rat model' parameters of sexual behavior and fertility were asessed including behavioral parameter as sniffing, investigating' mount, intromission' and ejaculation latency and frlquencies- ' Also serum prolactin and testosterone levels and semen analysis were checked in depressed rats in comparisin to the control normal rats and those