The effecr of diclo.fenac sociium, a porent prostaglandin syn_rhesis ;nrriuiroi' on spermaro- genesis and seminal parameters in normal and oligospermic marure ;",-;;;iia. buen studied. Diclofenac sodium. at a dose oi-.Z.Omg/ke was given subcuraneously once-;;i'tor 25 days ro normal and colchirine ;";j oligospermic adulr male rat m.odet. Th;';;;;d fluid para- merers were eyaluated. Testicular .tiri"rJs]"ll secrions and serum ..FlH, iii-"*o prolactin levels were_ also studieJ. -' tration produced C-J"li"in" adminis_ a ._marked -;; significant decrease ,;"il.i;,;ii; meters tp .o.oorl il"r"*inrl para- and spermato-genesis. ' ifr" administra_ tion of diclofenac ,od.ium in'. do;u of Z m{/,k,, . sc/day tor zs r""^::-:r-d o.r, J*;.r*o-jiJ,ii'i,.. canc sperm cell counr and viabiiiry,*prou"menr in colchicine reared ;;;.'*'ffieover, fenac sodium induced diclo_ -ro;ifiJ;; serum prolaerin decrease in level and- remarii"Ur.-i*irr""l menr in ail seminar, hor*oiui"'ino cesricurar parameters in oligosperric ruts.