In this study, the effects of fish diet contaminated with Cu, Cd and Cu + Cd on Nile tilapia, wasdemonstrated by evaluating its bioaccumulation in the muscle and by testing the cytogeneticprofile. Fish exposed to diet contaminated with Cu, Cd or their mixture had a significantincrease in the number of chromosomal abnormalities and an inhibition of the mitoticindex. Our study revealed high muscle Cu or Cd content in fish fed with diet contaminatedwith high dietborne Cu, Cd, Cu and Cd. It also revealed that the chromosomal abnormalitieswere higher for fish fed diet Cd contaminated and Cu + Cd contaminated diets than thosefed diet Cu contaminated diet. Thus, maybe fish diets contaminated with Cu, Cd, Cu + Cdinduced genotoxicity and mutation. Also, maybe high concentrations of Cu and Cd in fishtissue resulted from feeding on Cu and Cd contaminated diets, are dangerous for humanconsumption.