Staff Members - Benha University
Significance of intrarenal B and T lymphocytic infiltrates in lupus nephritis
• 2016
Publication Information
Authors
Nashwa M. Emara, Mona A. Abou Elmahasen, Eman Saad Omar, Adel Zaki El-saidy, Zeinab I. El shawarby and Samia A.Youssef
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publication.type
International
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Abstract
Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE). The true prevalence of clinical lupus nephritis in persons with SLE is probably around 50%, being higher in certain ethnic groups and in children.
It was hypothesized that intrarenal B cells form part of a local system with pivotal involvement in the pathogenesis of lupus nephritis. It enhances immunological responses and exaggerates the local immune response to persisting autoimmune damage in the tubulointerstitium. T cells cause tissue injury by activating and providing help to nephritogenic antibody-producing B cells, recruiting macrophages and dendritic cells (DCs), and producing cytokines.
Aim: This retrospective study aims to assess intrarenal B and T lymphocytic infilterates in cases of lupus nephritis using CD20 and CD3and determine their possible value in lupus nephritis and their possible relation to clinical outcome.
Results: Intrarenal B &T cells were more likely to be associated with class IV LN. LN activity index (AI), chronicity index (CI), proteinuria and serum creatinin had a significant statistical correlation with intrarenal B and T cell infiltrates.
It was hypothesized that intrarenal B cells form part of a local system with pivotal involvement in the pathogenesis of lupus nephritis. It enhances immunological responses and exaggerates the local immune response to persisting autoimmune damage in the tubulointerstitium. T cells cause tissue injury by activating and providing help to nephritogenic antibody-producing B cells, recruiting macrophages and dendritic cells (DCs), and producing cytokines.
Aim: This retrospective study aims to assess intrarenal B and T lymphocytic infilterates in cases of lupus nephritis using CD20 and CD3and determine their possible value in lupus nephritis and their possible relation to clinical outcome.
Results: Intrarenal B &T cells were more likely to be associated with class IV LN. LN activity index (AI), chronicity index (CI), proteinuria and serum creatinin had a significant statistical correlation with intrarenal B and T cell infiltrates.