Staff Members - Benha University
Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway
Biomedicine & Pharmacotherapy • 2022
Publication Information
Authors
Nesrine Ebrahim a,b , Heba Elsayed Abd El-Halim a , Omayma Kamel Helal a , Nahla El-Eraky El-Azab a , Omnia A.M. Badr c , Amira Hassouna d , Hajir A.Al Saihati e , Nashwa Hassan Aborayah f et al
Keywords
Diabetic retinopathy
Mesenchymal stem cells
Exosomes
Journal
Biomedicine & Pharmacotherapy
Publisher
Not Available
Volume
154
Issue
Not Available
Pages
1-23
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management of DR. Exosomes, considered as a
promising cell-free therapy option, display biological functions similar to those of their parent cells. In retinal
development, Wnt/b-catenin signaling provides key cues for functional progression. The present study aimed to
Abbreviations: Anti-VEGF, anti-vascular endothelial growth factor; BM-MSCs-Ex, bone marrow-derived mesenchymal stem cell-derived exosomes; DM, diabetes
mellitus; DR, diabetic retinopathy; Fz, frizzled; GCL, ganglionic cell layer; GFAP, glial fibrillary acidic protein; GSK3b, glycogen synthase kinase-3b; IHC, immunohistochemistry; ILM, inner limiting membrane; INL, inner nuclear layer; IPL, inner plexiform layer; LRP5/6, low-density lipoprotein receptor-related protein; NFL,
nerve fiber layer; OLM, outer limiting membrane; ONL, outer nuclear layer; PRL, photoreceptor layer; RPE, retinal pigment epithelial; STZ, streptozotocin; TNF-α,
tumor necrosis factor-α.
promising cell-free therapy option, display biological functions similar to those of their parent cells. In retinal
development, Wnt/b-catenin signaling provides key cues for functional progression. The present study aimed to
Abbreviations: Anti-VEGF, anti-vascular endothelial growth factor; BM-MSCs-Ex, bone marrow-derived mesenchymal stem cell-derived exosomes; DM, diabetes
mellitus; DR, diabetic retinopathy; Fz, frizzled; GCL, ganglionic cell layer; GFAP, glial fibrillary acidic protein; GSK3b, glycogen synthase kinase-3b; IHC, immunohistochemistry; ILM, inner limiting membrane; INL, inner nuclear layer; IPL, inner plexiform layer; LRP5/6, low-density lipoprotein receptor-related protein; NFL,
nerve fiber layer; OLM, outer limiting membrane; ONL, outer nuclear layer; PRL, photoreceptor layer; RPE, retinal pigment epithelial; STZ, streptozotocin; TNF-α,
tumor necrosis factor-α.