| publication name | Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway |
|---|---|
| Authors | Nesrine Ebrahim a,b , Heba Elsayed Abd El-Halim a , Omayma Kamel Helal a , Nahla El-Eraky El-Azab a , Omnia A.M. Badr c , Amira Hassouna d , Hajir A.Al Saihati e , Nashwa Hassan Aborayah f et al |
| year | 2022 |
| keywords | Diabetic retinopathy Mesenchymal stem cells Exosomes |
| journal | Biomedicine & Pharmacotherapy |
| volume | 154 |
| issue | Not Available |
| pages | 1-23 |
| publisher | Not Available |
| Local/International | International |
| Paper Link | https://pubmed.ncbi.nlm.nih.gov/35987163/ |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management of DR. Exosomes, considered as a promising cell-free therapy option, display biological functions similar to those of their parent cells. In retinal development, Wnt/b-catenin signaling provides key cues for functional progression. The present study aimed to Abbreviations: Anti-VEGF, anti-vascular endothelial growth factor; BM-MSCs-Ex, bone marrow-derived mesenchymal stem cell-derived exosomes; DM, diabetes mellitus; DR, diabetic retinopathy; Fz, frizzled; GCL, ganglionic cell layer; GFAP, glial fibrillary acidic protein; GSK3b, glycogen synthase kinase-3b; IHC, immunohistochemistry; ILM, inner limiting membrane; INL, inner nuclear layer; IPL, inner plexiform layer; LRP5/6, low-density lipoprotein receptor-related protein; NFL, nerve fiber layer; OLM, outer limiting membrane; ONL, outer nuclear layer; PRL, photoreceptor layer; RPE, retinal pigment epithelial; STZ, streptozotocin; TNF-α, tumor necrosis factor-α.