Staff Members - Benha University
A Histological and Immunohistochemical Study on Testicular Changes Induced by Sliver Nanoparticles in Adult Rats and the Possible Protective Role of Camel Milk
The Egyptian journal of histology • 2019
Publication Information
Authors
Nahla El-Eraky El-Azab and Abeer M. El-Mahalaway
Keywords
Bcl2, camel milk, PCNA, silver nanoparticles, testis.
Journal
The Egyptian journal of histology
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Introduction: Silver nanoparticles (AgNPs) are broadly used in medicine and food industry, associated with potential toxicity
in many organs. Camel milk (CM) is an excellent source of human nutrition and has many health benefits in prevention of
diseases.
Aim of the work: To assess the effect of two different doses of AgNPs on the testis of adult rats and the possible protective
role of CM.
Material and Methods: Forty-five adult male rats were divided into five groups, Group I: control rats, Group II: rats treated
with low dose of silver nanoparticles, Group III: rats treated with high dose of AgNPs, Group IV: rats treated with low dose of
AgNPs and camel milk, Group V: rats treated with high dose of AgNPs and camel milk. Testicular specimens were processed,
then examined histologically and immunohistochemically. Testosterone hormonal assay were done. Morphometrical studies
and statistical analysis were conducted.
Results: Group II showed mild harmful effect, while Group III had severe damaging changes on the seminiferous tubules.
They showed a significant increase (P < 0.01) of α-SMA, a significant decrease(P
in many organs. Camel milk (CM) is an excellent source of human nutrition and has many health benefits in prevention of
diseases.
Aim of the work: To assess the effect of two different doses of AgNPs on the testis of adult rats and the possible protective
role of CM.
Material and Methods: Forty-five adult male rats were divided into five groups, Group I: control rats, Group II: rats treated
with low dose of silver nanoparticles, Group III: rats treated with high dose of AgNPs, Group IV: rats treated with low dose of
AgNPs and camel milk, Group V: rats treated with high dose of AgNPs and camel milk. Testicular specimens were processed,
then examined histologically and immunohistochemically. Testosterone hormonal assay were done. Morphometrical studies
and statistical analysis were conducted.
Results: Group II showed mild harmful effect, while Group III had severe damaging changes on the seminiferous tubules.
They showed a significant increase (P < 0.01) of α-SMA, a significant decrease(P