The aim: was to evaluate the effect of nursing intervention to promote self care management practices for clients with Hepatitis ''C'' virus Design: a quasi-experimental design was used in carrying out this study. Setting: the study was conducted at the Medical Outpatients' Clinics of the Benha University Hospital in Benha City. The sample: A convenience sample was used included 100 HCV patients chosen randomly. Tools: utilized in this study comprised a structured interview questionnaire for assessment of the socio-demographic characteristics of HCV clients, the medical health status, their knowledge, self-care management practices, and an observational checklist through asking question for assessment of home environment. Results: the main results revealed that post the nursing intervention there was a significant improvement of client's knowledge about viral disease as causative agents of HCV, preventive measures, and self-care management about HCV practices of common health problems such as nutrition, itching, rest and exercises, depression, and muscle cramps. And, there was a positive correlation between client's knowledge, self care management practices, and home environment. This study concluded that, there was a significant positive effect of nursing intervention on knowledge and self-care management practices of HCV clients The study recommended that, promotion and enhancement of the self-care modalities to HCV clients, and mass media should be included in preventive measures programs of HCV problems, and further researches is proposed to explore factors affecting self care management in rural areas. [Naglaa M. Girgis, Nadia Hamed Farahat, and Hanan Ibrahim Ahmed . Nursing Intervention to Promote Self Care Management Practices for Clients with Hepatitis ''C'' Virus. J Am Sci 2012;8(7):581-591]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 89