The aim: of the study was to evaluate the effect of nursing intervention on daily living activities (DLAs) for family caregivers (FCGs) of Alzheimer clients. Design: This study is a quasi-experimental research design. Setting: This study was conducted at the Geriatric Outpatient Clinic and Alzheimer Outpatient Clinic at Ahmed Okasha Center in Ain-Shams University Hospitals Sample: A purposive sample of 60 Alzheimer clients and their family caregivers;32 from Alzheimer Outpatient Clinic at Ahmed Okasha Center; and 28 from Geriatric Outpatient Clinic. Tools: Data were collected using two tools. 1): An interviewing questionnaire, consisting of socio-demographic characteristics of FCGs of the Alzheimer clients, their needs for knowledge about Alzheimer disease (used pre/post program), their activities of daily living, toward their Alzheimer clients (used pre/post program), and there as physical, psychosocial, emotional and strain problems. 2): An observational checklist for assessing the Alzheimer clients' home environment. Results: The mmain results revealed that most of FCGs had physical and psychosocial strain problems, followed by emotional strain, and more than half of them had safe environment. There was a highly statistically significant difference between family caregivers' total knowledge, and providing DLAs towards their Alzheimer clients pre / post implementation of the program. As well there was a positive correlation with highly statistically significant difference between FCGs according to home environment and providing DLAs towards their Alzheimer clients’ pre / post program. Recommendations: Counseling and nursing intervention for FCGs of Alzheimer clients about knowledge of Alzheimer disease, DLAs, as well as emotional support and relieving stress, and prevention of environmental hazards.