Problem statement: Similar to obese patients and type 2 diabetic patients, adiponectin levels are ‎reduced in former Gestational Diabetes Mellitus (GDM) patients and are lower in GDM women during ‎late pregnancy compared with pregnant control subjects matched for BMI. Diabetic insult at later stages ‎in gestation, such as may occur in gestational diabetes, will foremost lead to short-term changes in a ‎variety of molecules for key functions including gene expression in the placenta. Approach: In this ‎study we assessed the expression of adiponectin receptors in human placenta to identify the site (s) of ‎expression and to clarify the effect of gestational diabetes in this expression. This study was carried on ‎‎10 normoglycemic pregnant women and 20 GDM women. The placental tissue was collected ‎immediately after delivery and tissue biopsies were taken from both fetal and maternal sides of each ‎placenta. One step-RT-PCR for ADIPOR1 and ADIPOR2 was done by Real Time PCR using Syber ‎Green technique. Relative quantification of mRNA of the ADIPOR1 and ADIPOR2 genes was measured ‎using ABI7900 Real Time machine. Results: Both types of Adiponectin Receptors (ADIPOR1 and ‎ADIPOR2) are expressed in human placenta. ADIPOR1 is more highly expressed than ADIPOR2 in ‎both fetal and maternal sides of GDM cases and normal pregnant women. ADIPOR1 mRNA expression ‎was significantly up regulated in GDM women compared to normal pregnant women, whereas no ‎significant difference in the expression of ADIPOR2 was detected between the two groups. There was ‎no evidence of maternal-fetal side difference in the expression of adiponectin receptors in GDM cases ‎but in normal pregnant women there is a statistically significant difference between both sides in the ‎expression of both ADIPOR1 and ADIPOR2. Conclusion: We concluded that adiponectin plays an ‎important role in mediation the glucose metabolism in fetal tissues through its receptors, mainly ‎Adiponectin Receptor 1 (ADIPOR1). ‎