‎Problem statement: Adiponectin is an adipocyte secreted hormones, exerts its effects via the specific ‎receptors. AdipoR1 and adipoR2 and plays a pivotal role in lipid and glucose metabolism. Approach: ‎We investigated the effect of increased physical activities on insulin resistance and if this effect is ‎modulated through adiponectin receptor expression. Results: We also assessed the effect of High Fat ‎Diet (HFD) on adipoRs expression. Mice were subjected to 16 weeks of HFD protocol then to 4, 6 and 8 ‎weeks of exercise training. Following the experimental protocol the fasting plasma glucose, insulin and ‎index of Homeostasis Model Assessment of insulin Resistance (HOMA-R) were evaluated. The mRNA ‎expression of adiponectin receptors genes were also analyzed using reverse transcription RT-PCR. The ‎consumption of high fat diet by the mice for 16 weeks resulted in a significant increase in weight ‎associated with insulin resistance and associated with significant decrease in adiponectin receptors R1 ‎and R2 expression in both liver and skeletal muscle. Exercise training for 4 weeks resulted in a ‎significant improvement in the insulin resistance state, significant increase in expression of AdipoR1 and ‎AdipoR2 in both liver and skeletal muscles. On increasing duration of exercise training for 6 weeks and ‎‎8 weeks there was significant improvement in insulin resistance and significant increase in the ‎expression of AdipoR1 in liver, AdipoR1 and AdipoR2 in muscle, whereas liver AdipoR2 expression was ‎significantly decreased. Conclusion/Recommendations: we conclude that the exercise training ‎improves insulin sensitivity and up-regulates mRNA expression of AdipoR1 in both skeletal muscle and ‎liver in mice and AdiopR2 in muscle and this suggests that the insulin sensitizing effect of exercise ‎training may be mediated even partially through increased adiponectin receptor expression and up ‎regulation of adiponectin receptors reaches certain level and increasing the duration of exercise adds no ‎more improvement to insulin sensitivity or adiponectin receptor expression. ‎