Problem statement: Hepatocellular carcinoma will emerge as a major form of malignancy in the coming ‎decades. The continuing high incidence of hepatocellular carcinoma, suggests that this disease will continue ‎to represent a global health problem far into the future. Different genes encode for the various components ‎of the human telomerase complex. These components include the human Telomerase RNA Component ‎‎(hTERC) and the Telomerase Catalytic Subunit (hTERT). Correlation between Telomerase Reverse ‎Transcriptase (hTERT) expression and telomerase activity has been reported in cancer patients. This work ‎aimed to clarify the significance of human Telomerase Reverse Transcriptase (hTERT mRNA) as a potential ‎molecular tumor marker for Hepatocellular Carcinoma (HCC). Approach: The current study included 25 ‎patients of hepatocellular carcinoma (HCC), 30 patients with liver cirrhosis and 25 age and sex matched ‎individuals with normal laboratory and Image findings as a control group. hTERT mRNA was measured in ‎plasma by Real time PCR in all patients samples in comparison with normal healthy controls. Results: The ‎expression of hTERT mRNA by relative unit was 129.10±27.6 with range (67.72-69.6) Vs 5245.87±2382.48 ‎‎(2053-12232.90) Vs 92782.76±16158 (61783.25-118596.47) for control Vs cirrhosis Vs HCC group ‎respectively. The hTERT expression was significantly with 699 and 33 fold increase in HCC and cirrhosis ‎groups correspondingly when compared to that of controls p<0.05. Conclusion: It was suggested that this ‎procedure was highly discriminating between healthy subjects and cancer patients and strongly support the ‎idea that a valuable diagnostic test for cancer might be developed using this genetic marker in plasma. ‎However it needs to be combined with other markers in future studies to be more specific for liver cancer. ‎