Background: Collaboration between nurses and physicians is linked to positive outcomes for patients, especially in psychiatric units. However, effective collaboration poses challenges as work stressors. So, effective work stressors coping strategies have the highly concern from organization management as a method for maintaining high level of collaboration. Aim: This study aimed to explore the effect of working stressors coping strategies program on nurse physician collaboration. Design: Quasi experimental design was used. Setting: This study was carried out at Benha psychiatric hospital. Sample: All convenient nurses and physicians worked at in-patient care units. Tools: Two tools were used, questionnaire to assess work stressors and collaborative practice scale (CPS) questionnaire. Result: There is a negative correlation between work stressors and nurse-physician collaboration (P