Acute kidney injury (AKI) post cardiac surgical incidence varies between 5% and 30%. Acute kidney injury is associated with an increased risk of mortality and morbidity, predisposes patients to a longer hospitalization, requires additional treatments, and increases the hospital costs, acute kidney injury is characterized by a progressive worsening course, being the consequence of an interplay of different path physiological mechanisms, with patient-related factors and as major causes by cardiopulmonary bypass