Staff Members - Benha University
Synthesis of a 188Re–DTPMP complex using carrier-free 188Re and study of its stability
Journal of Radioanalytical and Nuclear Chemistry • 2011
Publication Information
Authors
M. Y. Nassar • M. T. El-Kolaly • M. R. H. Mahran
Keywords
Not Available
Journal
Journal of Radioanalytical and Nuclear Chemistry
Publisher
Springer
Volume
287
Issue
Not Available
Pages
779-785
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Labeling of diethylenetriamine-N,N,N0,N00,N00-
pentakis(methylenephosphonic) acid (DTPMP) with rhenium-
188 using stannous chloride as a reducing agent has
been investigated. Dependence of the yield of the 188Re–
DTPMP complex on the concentration of the reducing
agent, pH, reaction time, temperature, ascorbic acid and
amount of carrier added has been studied. Under optimum
conditions, the labeling yield of 188Re–DTPMP complex is
95% for the carrier-free 188Re but with the carrier-added
188Re the labeling yield is more than 97%. Furthermore, the
stability of the 188Re–DTPMP complex against pH change
and dilution with saline has been also studied. It is found
that the addition of carrier stabilizes the 188Re–DTPMP
complex against pH change and dilution.
pentakis(methylenephosphonic) acid (DTPMP) with rhenium-
188 using stannous chloride as a reducing agent has
been investigated. Dependence of the yield of the 188Re–
DTPMP complex on the concentration of the reducing
agent, pH, reaction time, temperature, ascorbic acid and
amount of carrier added has been studied. Under optimum
conditions, the labeling yield of 188Re–DTPMP complex is
95% for the carrier-free 188Re but with the carrier-added
188Re the labeling yield is more than 97%. Furthermore, the
stability of the 188Re–DTPMP complex against pH change
and dilution with saline has been also studied. It is found
that the addition of carrier stabilizes the 188Re–DTPMP
complex against pH change and dilution.