Objectives: To study the effect of agnucaston with clomiphen citrate in infertile patients with polycystic ovaries. Study type: Controlled trial. Materials and Methods: One hundred infertile cases with polycystic ovaries randomized into two groups fifty (50) cases received clomiphen citrate 50 mg from second day of menstruation two tablets per day for 5 days in addition with agnucaston (agnus castus, Binoreca) two tablets per day from the first day of menstruation for 14 days the other group received only clomiphen citrate 50 mg two tablets per day from second day for 5 days. Results: Group 1(combined agnucaston with clomiphen citrate the pregnancy rate is 30 out of 50 (60%) while the second group the (clomiphen only group) pregnancy rate is 15 out of 50 (30%).