Objectives: The objective is to compare the new short protocol with traditional short protocol in ICSI programs. Study design: Controlled trial. Materials and methods: 40 cases scheduled for ICSI after a variable period of infertility classified into two groups according to stimulation protocol. group1(20 case) with fixed 2 dose regimen (given merional ampoules) 4 ampoules first four days of stimulation the 3 ampoules thereafter while the other 20 patients given the traditional short protocol starting with 3 ampoules then dose adjusted according to patient response. Results: Days of stimulation, Number of merional ampoules, were significantly less in the new modified short protocol than in the classic short protocol; while number of M2 oocytes, number of good embryos, pregnancy rate were significantly high in the group 1. Pregnancy rate was 75% in the new modified protocol and 50% with the classic short protocol. Conclusion: The new short fixed 2 dose short protocol regimen offers a benefit in all the ways in ICSI success and pregnancy rate with less time of gonadotropin stimulation and less cost.