Thermal radiation, thermal diffusion, and diffusion-thermo effects on heat and mass transfer by mixed convection of non-Newtonian power-law fluids over a vertical permeable surface embedded in a saturated porous medium are investigated. The governing equations describing the problem are non-dimensionalized and transformed into a non-similar form. The transformed equations are solved by using the local non-similarity method combined with the shooting technique. The effects of the physical parameters of the problem on the fluid temperature and concentration are illustrated graphically and analyzed. Also, the effects of the pertinent parameters on the local Nusselt number and the local Sherwood number are presented.