Long-range wide area network (LoRaWAN) is a promising low-power network standard that allows for longdistance wireless communication with great power saving. LoRa is based on pure ALOHA protocol for channel access, which causes collisions for the transmitted packets. The collisions may occur in two scenarios, namely the intra-spreading factor (intra-SF) and the inter-spreading factor (inter-SF) interference. Consequently, the SFs assignment is a very critical task for the network performance. This paper investigates a smart SFs assignment technique to reduce collisions probability and improve the network performance. In this work, we exploit different architectures of artificial neural networks for detecting collisions and selecting the optimal SF. The results show that the investigated technique achieves a higher prediction accuracy than traditional machine learning algorithms and enhances the energy consumption of the network.