Background: The Keloid is an elevated fibrous scar that may extend beyond the borders of the
original wound.
Object: To compare between topical and intralesional mitomycin C in the treatment of auricular
keloids.
Patients and methods: Prospective randomized study in which 40 patients with auricular keloids
were included. The patients were divided into 2 groups, Group I included 32 patients who
underwent topical mitomycin C application after the surgical removal of the auricular keloids,
while Group II included 8 cases who underwent intra-lesional injection of mitomycin C after
surgical removal of the auricular keloids.
Results: The two groups showed no significant difference regarding patient or lesion criteria
(p > .05). VSS decreased significantly from 10.63 and 11.0 down to 1.38 and 3.0 after treatment
in the topical and intra-lesional groups respectively (p < .001). However, greater improvement
and satisfaction was detected in the topical group.
Conclusion: Both topical and intra-lesional mitomycin C injection are effective methods in
managing auricular keloids. However, better VSS scores and patient satisfaction are reported
with topical administration