Zag. Med. Ass. J. 7(3) July Study of changes in fibrocelluler components of bilharzial granuloma in different stages of infection and treatment. Fargaly A. M. , El-Kateb M. I. ,Makary R. E., Raefa A. Moula, Soad M. Yousef and Mona E. Nasr: (1994). Liver and intestine of mice infected with Schistosoma mansoni were examined for modulation in granuloma size, monber, site, and fibrocellular constituents at different periods of infection and treatment with praziquantel. The main modulation was a decrease in granuloma size observed early in the liver (12th week of infection) and continued up to 24 weeks after infection. In the intestine size modulation started later (16th week of infection) and was less marked than in the liver. Also fibrosis was much less as compared to hepatic fibrosis. After praziquantel treatment a rapid and completed healing of intestinal granulomatous reactions occurred 12 weeks following therapy. In the liver, despite the marked improvement of hepatic lesions, the healing process was slower extending up to 16 weeks after treatment leaving residual few small fibrotic granuloma.