E learning is a formalized teaching with the aid of electronic resources where in education can be delivered to large number of students (the target audience) at same or different time. The synchronized e-learning was the panacea at the time of the covid- 19 pandemic. However, it negatively influenced the learners’ performance, attitude and learning outcomes. Aim: To assess the effect of obstacles faced nursing students related applying e-learning during COVID-19 pandemic on their attitudes. A descriptive correlational study design was used. The research was carried out at Benha University's Faculty of Nursing in Egypt. Subjects: During the academic year 2020/2021, a stratified random sampling technique was used to choose 25% of students from each of the four academic years enrolled in the Faculty of Nursing at Benha University. Tools: Interviewing questionnaire, attitude towards e-learning scale and obstacles of e-learning questionnaires. Results: 55.5 % of students expressed negative attitudes regarding e-learning, according to the findings. The highest level of total obstacles presented among academic students in the first year (66.8%) and the lowest level of total obstacles presented among academic students in the fourth year (57%) were encountered by nursing students when using e-learning. The most common dimensions of obstacles to e-learning were infrastructure and technological advancements, technical and managerial assistance and instructors' characteristics (88.2%, 86.3% and 83.3% respectively). Conclusions: There was a highly statistically significant negative correlation between obstacles facing nursing students and their attitudes towards e-learning. Recommendation: In light of the uniqueness of learning programs, the study proposes that higher education institutions improve their e-learning strategy in order to encourage students' academic achievement