Depression and anxiety are most prevalent in patients with leprosy, which impact the quality of life of patients. Aims: This study aimed to assess psychological problems and quality of life among leprosy patients, and to investigate the relationship between psychological problems and quality of life among leprosy patients. Methods: A Descriptive correlational design utilized to fulfill the aim of this study. The study conducted at the Dermatology & Leprosy clinic in Benha City, Kaluobia Governorate, which affiliated to the Ministry of Health. A descriptive study among 100 leprosy patients was recruited consecutively from dermatology and leprosy outpatient. Three tools were used to achieve the aim of this study. A structured Interviewing schedule, the World Health Organization Quality of Life (WHOQOL)-BREF Questionnaire, and Depression Anxiety Stress Scales (DASS). Results: The majority of the studied patients had a low level of quality of life, Also, two thirds had a moderate level of depression, and about two thirds of them had sever level of anxiety, while the majority of them had a moderate level of stress; also, more than half of them had a severe level of total DASS. Also, a statistically significant negative correlation between the total quality of life and total DASS among the studied patient with leprosy at p-value =