Staff Members - Benha University
Serum and synovial matrix metalloproteinase-3 as markers of disease activity in early rheumatoid arthritis
• 2016
Publication Information
Authors
Rasha M. Fawzy1, Yasser A. Abdel Hamid2, Mona M. Albehesy3,
Rasha F. Aboelmaged4
Keywords
matrix metalloproteinase-3, rheumatoid arthritis, synovial fluid
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background
Matrix metalloprotein ase-3 (MMP-3) is one of the MMPs produced in rheumatoid
arthritis (RA) joints.
Aim
The aim of this study was to evaluate serum and synovial fluid (SF) MMP-3 as
markers of disease activity in early RA.
Patients and methods
Thirty early RA patients together with age-matched and sex-matched 12 primary
knee osteoarthritis patients and 12 apparently healthy individuals as control groups
were enrolled in this study. MMP-3 was measured in serum and SF samples using
enzyme-linked immunosorbent assay. Assessment of disease activity in RA
patients was carried out using disease activity score-28 (DAS-28), and
radiographs of the hands, wrists, and forefeet were obtained and evaluated
according to Larsen score.
Results
As regards mean serum levels of MMP-3, there was a statistically significant
elevation in RA patients compared with the control groups (P
Matrix metalloprotein ase-3 (MMP-3) is one of the MMPs produced in rheumatoid
arthritis (RA) joints.
Aim
The aim of this study was to evaluate serum and synovial fluid (SF) MMP-3 as
markers of disease activity in early RA.
Patients and methods
Thirty early RA patients together with age-matched and sex-matched 12 primary
knee osteoarthritis patients and 12 apparently healthy individuals as control groups
were enrolled in this study. MMP-3 was measured in serum and SF samples using
enzyme-linked immunosorbent assay. Assessment of disease activity in RA
patients was carried out using disease activity score-28 (DAS-28), and
radiographs of the hands, wrists, and forefeet were obtained and evaluated
according to Larsen score.
Results
As regards mean serum levels of MMP-3, there was a statistically significant
elevation in RA patients compared with the control groups (P