The present study evaluate the deleterious effect of some industrial establishment disposing their discharge into Ismailia canal at its passage via Abou Zabal and Mostorod (Kaluobia Governorrate). We selected four major point sources of pollution where water samples were collected nearby and at some distances from the outlet of the industrial establishment under investigation. Also samples of fish (Tilapia nilotica sp.) were collected from the same sources by fishermen. The level of some heavy metals "lead, cadmium, mercury. and iron" were measured in both water and fish. The results indicated a positive correlation between the location of the point source of pollution and the load of heavy metals in water and fish. Furthermore the study indicated that fish is a very good indication for water pollution resulted from industrial discharges as it reflects not only water pollution but also bioavilability of individual metal contaminants in living organisms when present collectively in a mixture.