Background: life style modification most important in the management of ischemic heart disease patients. Aim: The study aimed to evaluate the effect of implementing designed life style modification program on outcomes among patients' with ischemic heart disease. Design: Quasiexperimental research design was utilized in this study. Setting: The study was carried out in (CCU) and cardiology out-patient clinics at Benha University Hospital. Sample: Purposive sample of patients with diagnosis ischemic heart disease who is admitted in mentioned setting of the study during the six months. Tools: two tools were used, Tool (1): Structured interviewing questionnaire part one demographic characteristics and part two Assessment of patient's lifestyle practices regarding IHD; tool (2): Patients' clinical outcomes to assess patients' life style practice modification regarding IHD. Results: The study reveal that the most of studied patients (99%) had poor total knowledge level regarding ischemic heart disease at pre life style modification program implementation, while, immediately post implementation more than three quarter of them (79%) had good level of knowledge and after three months there was slightly decline in their level of knowledge (55%).respectively with a highly statistically significant difference at (p≤0.001). Conclusion: Providing life style modification program has been shown to be effective on patients ' modification life style practice regarding IHD. Recommendation: Continuous education and training of patients regarding life style modification for IHD patients.