Staff Members - Benha University
Immunohistochemical Differentiation between Reactive and Malignant Mesothelial Proliferations in Pleural Effusio
• 2020
Publication Information
Authors
MOHEBAT H. GOUDA, M.D.*; MOHAMMED ELMAHDY, M.D.** and GEHAN M. ELOSEILY, M.
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publication.type
Local
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Abstract
Background: The differentiation between benign and malignant mesothelial cells in pleural effusion in some cases can be a challenge. In the current study, we investigated the value of immunohistochemistry (IHC) in making that differentiation.
Aim of Study: This study aims to examine the value of IHC expression of desmin, EMA, GLUT-1, p53, Ki67, and BAP1 in discrimination between benign and malignant mesothelial proliferation in pleural effusions and compare their results regarding sensitivity and specificity.
Material and Methods: Pleural fluids from 30 cases diagnosed as malignant meothelioma (MM) epitheloid type and 20 cases diagnosed as reactive mesothelial hyperplasia (RMH) were selected, and stained with immunohistochemical stains included BAP-1, desmin, epithelial membrane antigen (EMA), glucose-transport protein 1 (GLUTÅ]1), Ki67, and p53.
Results: BAP-1 was negative in 5% (1 of 20) cases of reactive MH and in 63.3% (19 of 30) of MM cases (p
Aim of Study: This study aims to examine the value of IHC expression of desmin, EMA, GLUT-1, p53, Ki67, and BAP1 in discrimination between benign and malignant mesothelial proliferation in pleural effusions and compare their results regarding sensitivity and specificity.
Material and Methods: Pleural fluids from 30 cases diagnosed as malignant meothelioma (MM) epitheloid type and 20 cases diagnosed as reactive mesothelial hyperplasia (RMH) were selected, and stained with immunohistochemical stains included BAP-1, desmin, epithelial membrane antigen (EMA), glucose-transport protein 1 (GLUTÅ]1), Ki67, and p53.
Results: BAP-1 was negative in 5% (1 of 20) cases of reactive MH and in 63.3% (19 of 30) of MM cases (p